oOxyntic/ stomachic glands: Located on the intimate surfaces of the body and fundus of the stomach Constitute the proximal 80% of the stomach A typical gland is composed of 3 types of cells: mucous neck cells which secrete mainly mucus; peptic/chief cells which secrete rotund quantities of pepsinogen; parietal/oxyntic cells which secrete hydrochloric acid (gastric acid) and intrinsic factor oPyloric glands: Are located in the antral portion of the stomach suck up the distal 20% of the stomach resign mainly mucus for protection of the pyloric mucosa from gastric acid; also secrete the hormone gastrin and a midget keep down of pepsinogen oPepsinogen: Secreted mainly by peptic cells of the oxyntic glands, and a small amount is also secreted from the mucous cells of the oxyntic glands and from the pyloric glands (function is the same) Molecular weight = c. 42,500 Da Is nonoperational when first secreted into the into the stomach Is activated to sticking plaster cast pepsin: during this process, pepsinogen is split into a 35,000 Da molecule (pepsin) HCl creates an caustic purlieu which allows pepsinogen to unfold and cleave itself in an autocatalytic fashion, thereby generating pepsin Pepsin acts as an...If you want to get a full essay, order it on our website: Ordercustompaper.com
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